Why and how did that happen to Him?

Because He presented Himself to God in order to make satisfaction in the name of sinners, it was necessary that He should suffer fearful distress of conscience, as if He had been forsaken by God, and even as if God had become hostile to Him. It was in this extremity that He cried, "My God, my God, why hast thou forsaken me " (Mat 27:46; Mark 15:34).